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Effects of Periodontitis on Heart Rate Variability
Sponsor: University of Sao Paulo
Summary
Periodontitis is a chronic inflammatory disease associated with systemic inflammatory burden and possible alterations in autonomic nervous system regulation. Heart rate variability (HRV) has been used as a noninvasive method to assess autonomic modulation and may reflect sympathovagal imbalance associated with inflammatory conditions. This case-control study aims to investigate the association between periodontitis and autonomic modulation assessed by HRV parameters. In addition, the study will evaluate the association between periodontal clinical parameters, HRV indices, and plasma levels of pro- and anti-inflammatory cytokines and biomarkers. Participants with and without periodontitis will undergo periodontal examination, HRV assessment, and blood sample collection for inflammatory marker analyses.
Official title: Study of Autonomic Modulation - Sympathetic and Parasympathetic - in Periodontitis Through Heart Rate Variability
Key Details
Gender
All
Age Range
35 Years - 50 Years
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2023-07-01
Completion Date
2027-04
Last Updated
2026-07-29
Healthy Volunteers
Yes
Conditions
Interventions
Non-surgical periodontal therapy
Non-surgical periodontal treatment including oral hygiene instruction, supragingival scaling, scaling and root planing, and periodontal maintenance therapy.
Locations (1)
FORP-USP
Ribeirão Preto, São Paulo, Brazil