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Dose-response Effects of Dietary Nitrate on Running Time-to-exhaustion and Neuromuscular Fatigue: a Randomized Crossover Exploratory Pilot Study
Sponsor: Universidad Autonoma de Madrid
Summary
Background: Dietary nitrate is a natural compound found in vegetables such as beetroot and leafy greens. Previous research suggests that consuming nitrate before exercise may improve endurance and physical performance. However, it is still unclear whether higher doses provide greater benefits, particularly in recreationally trained individuals. Purpose: This study aimed to investigate whether different doses of dietary nitrate taken before exercise influence endurance performance and muscle fatigue during a running test in recreationally trained men. Methods: This randomized, double-blind, placebo-controlled crossover pilot study compared the effects of a placebo and three different doses of dietary nitrate consumed before exercise. On separate occasions, participants completed the same treadmill running test to exhaustion after ingesting the assigned supplement. Measures of muscle performance, blood lactate concentration, and perceived exertion were collected before and after exercise to evaluate the effects of dietary nitrate supplementation.
Key Details
Gender
MALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
9
Start Date
2023-10-01
Completion Date
2025-09-30
Last Updated
2026-07-30
Healthy Volunteers
Yes
Conditions
Interventions
Dietary Nitrate
Participants received a single acute dose of dietary nitrate before exercise. Three doses were evaluated (4.8 mmol, 8.1 mmol, and 11.3 mmol), administered approximately 2.5 hours before the treadmill running test.
Placebo
Participants received a nitrate-depleted placebo beverage approximately 2.5 hours before the treadmill running test.
Locations (1)
Universidad Autónoma de Madrid
Madrid, Madrid, Spain