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NOT YET RECRUITING
NCT07735546
PHASE1

A Phase 1 Study of UB-VV500 With Rapamycin in Relapsed/Refractory Multiple Myeloma

Sponsor: Umoja Biopharma

View on ClinicalTrials.gov

Summary

This study is a Phase 1 dose-finding and dose-confirmation study to evaluate the safety and antitumor activity of UB-VV500. The study will enroll patients with relapsed/refractory multiple myeloma.

Official title: A Phase 1, Open-label, Multicenter Study of UB-VV500 With Rapamycin in Relapsed or Refractory Multiple Myeloma

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

100

Start Date

2026-10-01

Completion Date

2029-12-31

Last Updated

2026-07-30

Healthy Volunteers

No

Interventions

GENETIC

UB-VV500

UB-VV500 is a gene therapy that generates CAR T cells that target both B-cell maturation antigen (BCMA) and G protein-coupled receptor, family C, group 5, member D (GPRC5D) in the body.

DRUG

Rapamycin (sirolimus)

Rapamycin is a drug approved by the FDA for indications unrelated to cancer.