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Prospective Cohort Study of Adding Ovarian Function Suppression to Tamoxifen in Young Women With Hormone-sensitive Breast Cancer Who Remain Premenopausal or Resume Menstruation After Chemotherapy
Sponsor: MedicalExcellence
Summary
This study evaluates the long-term effects of adding 2 years of ovarian function suppression (OFS) to tamoxifen therapy in young premenopausal women with hormone receptor-positive breast cancer after chemotherapy. The study will assess recurrence, breast cancer-specific survival, and overall survival beyond 10 years to determine the long-term benefits of OFS treatment.
Official title: Prospective Cohort Study of Adding Ovarian Function Suppression to Tamoxifen in Young Women With Hormone-sensitive Breast Cancer Who Remain Premenopausal or Resume Menstruation After Chemotherapy: ASTRRA- IV Study
Key Details
Gender
FEMALE
Age Range
20 Years - 45 Years
Study Type
OBSERVATIONAL
Enrollment
1483
Start Date
2026-07-01
Completion Date
2034-05-01
Last Updated
2026-07-30
Healthy Volunteers
No
Conditions
Locations (1)
Asan Medical Center
Seoul, Sondpagu, South Korea