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Embolization of Genicular Arteries for Treatment of Symptomatic Knee Osteoarthritis
Sponsor: Assiut University
Summary
To evaluate the efficacy and safety of genicular artery embolization in patients with symptomatic knee osteoarthritis refractory to conservative treatment.
Official title: Super Selective Angiographic Catheterization and Embolization of Genicular Arteries for Treatment of Symptomatic Knee Osteoarthritis
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2026-08
Completion Date
2028-09
Last Updated
2026-07-30
Healthy Volunteers
No
Conditions
Interventions
suerselective angioembolization of genicular artery in symptomatic knee OA
Common femoral artery access will be obtained using ultrasound guidance. A 4-Fr or 5-Fr vascular sheath will be inserted. 5 Fr copra catheter or 5 Fr pernst catheters with be used. Diagnostic Angiography Selective angiography of one or more of the following arteries will be performed using microcatheter : * Superior medial genicular artery. * Superior lateral genicular artery. * Inferior medial genicular artery. * Inferior lateral genicular artery. * Descending genicular artery. * Recurrent tibial artery branches. Abnormal findings suggestive of synovial inflammation include: * Hypervascular blush. * Tumor-like neovascularity. * Early venous filling. * Increased periarticular vascularity. Superselective Embolization A microcatheter (1.7-2.4 Fr) will be advanced into target vessels. Embolization will be performed using one of the following agents: * Imipenem/Cilastatin suspension. * Polyvinyl alcohol particles (100-300 μm). * Microspheres (100-300 μm).