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Drospirenone-Primed Ovarian Stimulation Versus GnRH Antagonist Protocol in Poor Ovarian Responders Undergoing Freeze-All IVF/ICSI
Sponsor: Ahmed Saad
Summary
Participants will: * Take either drospirenone (a daily pill) or the standard daily injection during their ovarian stimulation cycle, alongside their regular fertility hormone injections * Undergo egg retrieval, with all resulting embryos frozen (no fresh embryo transfer in this study) * Have a frozen embryo transferred in a later cycle * Complete two short questionnaires about their treatment experience - once before starting the injections/pills, and once after the stimulation phase ends * Be followed to determine if the embryo transfer results in a pregnancy
Official title: Drospirenone-Primed Ovarian Stimulation (PPOS) Versus Flexible GnRH Antagonist Protocol in Poor Ovarian Responders Undergoing a Freeze-All Strategy: A Pilot Randomized Controlled Trial
Key Details
Gender
FEMALE
Age Range
20 Years - 42 Years
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2026-08
Completion Date
2027-11
Last Updated
2026-07-30
Healthy Volunteers
No
Interventions
Drospirenone drug
A drug drospirenone in the form of 1 tablet / d from 14 mm follicle till hCG trigger day
Cetrorelix 0.25 mg
Cetrorelix a drug injection daily sc. from 14 mm follicle till hCG trigger day
Locations (1)
Hawaa Fertility Center
Banhā, Qalyubia Governorate, Egypt