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Photodynamic Therapy for Preventing Recurrent Chromogenic Stains on Deciduous Teeth
Sponsor: Cairo University
Summary
Chromogenic extrinsic stains are common in children and frequently recur following conventional prophylaxis. Antimicrobial photodynamic therapy (aPDT) using methylene blue activated by red light has demonstrated antimicrobial activity against oral biofilm and may reduce stain recurrence. This pilot controlled clinical trial aims to compare conventional prophylaxis combined with methylene blue-mediated antimicrobial photodynamic therapy with conventional prophylaxis alone for preventing recurrent chromogenic extrinsic stains on deciduous teeth.
Official title: Antimicrobial Methylene Blue Photodynamic Therapy Versus Conventional Prophylaxis for Preventing Recurrent Chromogenic Stains on Deciduous Teeth: A Pilot Controlled Trial
Key Details
Gender
All
Age Range
4 Years - 6 Years
Study Type
INTERVENTIONAL
Enrollment
36
Start Date
2026-09-01
Completion Date
2027-07-01
Last Updated
2026-07-30
Healthy Volunteers
No
Conditions
Interventions
Antimicrobial Photodynamic Therapy
Conventional prophylaxis followed by topical application of methylene blue activated by 660-nm red light for antimicrobial photodynamic therapy.
Conventional Prophylaxis
Standard mechanical prophylaxis using rubber-cup polishing and prophylaxis paste.
Locations (1)
Cairo University
Cairo, Cairo Governorate, Egypt