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Invasive Vagus Nerve Stimulation Paired With Rehabilitation After Stroke
Sponsor: Beijing Chao Yang Hospital
Summary
This study evaluated the feasibility, safety, and preliminary functional outcomes of invasive vagus nerve stimulation (iVNS) paired with upper-limb rehabilitation in participants with chronic stroke-related upper-limb motor dysfunction. Participants received cervical iVNS implantation followed by a 6-week supervised rehabilitation program and subsequent home-based rehabilitation. Changes in upper-limb motor function, spasticity, quality of life, and safety outcomes were assessed. Exploratory neuroimaging assessments using positron emission tomography/computed tomography and arterial spin labeling were performed in selected participants to evaluate changes in brain metabolism and perfusion.
Official title: A Retrospective Cohort Study of Invasive Vagus Nerve Stimulation Paired With Rehabilitation for Upper Limb Dysfunction After Stroke
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
12
Start Date
2025-01-10
Completion Date
2026-03-15
Last Updated
2026-07-30
Healthy Volunteers
No
Interventions
Invasive Vagus Nerve Stimulation
Participants received left cervical invasive vagus nerve stimulation using an implanted pulse generator and electrode system, combined with structured upper-limb rehabilitation. Stimulation parameters were adjusted according to individual tolerance. Rehabilitation included supervised in-clinic training followed by home-based rehabilitation.
Locations (1)
Beijing Chao-Yang Hospital, Capital Medical University
Beijing, Beijing Municipality, China