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Ruscus Evaluation for Symptom Control in Uncomplicated Chronic Venous Insufficiency
Sponsor: Turkish Society for Vascular and Endovascular Surgery
Summary
This multicenter, prospective, observational study aims to generate and analyze real-world data on the effectiveness and safety of Ruscus aculeatus L. treatment in patients with symptomatic chronic venous disease classified as CEAP C1-C6. Patients receiving Ruscus aculeatus L. as part of routine clinical practice will be followed for 90 days without any study-mandated intervention. Disease severity will be assessed using the revised Venous Clinical Severity Score (rVCSS), pain using the Visual Analog Scale (VAS), quality of life using the Chronic Venous Disease Quality of Life Questionnaire (CIVIQ-20), treatment adherence using the Visual Analog Scale for adherence (VAS-U), and safety through the collection of adverse events during the observation period.
Official title: Evaluation of the Effects of Ruscus Aculeatus L. on Clinical Course and Quality of Life, and Assessment of Treatment Adherence and Tolerability in the Treatment of Chronic Venous Insufficiency: A Multicenter, Prospective, Observational Study
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
OBSERVATIONAL
Enrollment
564
Start Date
2026-06-02
Completion Date
2027-06-01
Last Updated
2026-07-30
Healthy Volunteers
No
Conditions
Locations (25)
Ankara Training and Research Hospital
Ankara, Ankara, Turkey (Türkiye)
Ankara University Faculty of Medicine Hospital
Ankara, Ankara, Turkey (Türkiye)
Bilkent City Hospital
Ankara, Ankara, Turkey (Türkiye)
Etlik City Hospital
Ankara, Ankara, Turkey (Türkiye)
Gazi University Faculty of Medicine Hospital
Ankara, Ankara, Turkey (Türkiye)
SBU Gulhane Training and Research Hospital
Ankara, Ankara, Turkey (Türkiye)
SBU Sincan Training and Research Hospital
Ankara, Ankara, Turkey (Türkiye)
Yıldırım Beyazıt University Yenimahalle Training and Research Hospital
Ankara, Ankara, Turkey (Türkiye)
Gaziantep University Faculty of Medicine Hospital
Gaziantep, Gaziantep, Turkey (Türkiye)
Mustafa Kemal University Hospital
Antakya, Hatay, Turkey (Türkiye)
Bagcilar Training and Research Hospital
Istanbul, Istanbul, Turkey (Türkiye)
Bahcelievler State Hospital
Istanbul, Istanbul, Turkey (Türkiye)
Bakırköy Sadi Konuk Eğitim Araştırma Hastanesi
Istanbul, Istanbul, Turkey (Türkiye)
Bezmiâlem Foundation University Hospital
Istanbul, Istanbul, Turkey (Türkiye)
Kartal Dr. Lütfi Kırdar City Hospital
Istanbul, Istanbul, Turkey (Türkiye)
Koşuyolu High Specialization Training and Research Hospital
Istanbul, Istanbul, Turkey (Türkiye)
Prof. Dr. Cemil Taşcıoğlu City Hospital
Istanbul, Istanbul, Turkey (Türkiye)
SBÜ Şişli Hamidiye Etfal Training and Research Hospital
Istanbul, Istanbul, Turkey (Türkiye)
Bakırçay Üniversitesi Çiğli Eğitim ve Araştırma Hastanesi
Izmir, İzmir, Turkey (Türkiye)
Ege University Faculty of Medicine Hospital
Izmir, İzmir, Turkey (Türkiye)
Kahramanmaraş Sütçü İmam University Faculty of Medicine
Kahramanmaraş, Kahramanmaraş, Turkey (Türkiye)
Necmettin Erbakan University Meram Faculty of Medicine Hospital
Konya, Konya, Turkey (Türkiye)
Inonu University Turgut Ozal Medical Center
Malatya, Malatya, Turkey (Türkiye)
Sivas Cumhuriyet University Faculty of Medicine Research and Application Hospital
Sivas, Sivas, Turkey (Türkiye)
Antalya City Hospital
Antalya, Turkey (Türkiye)