Clinical Research Directory
Browse clinical research sites, groups, and studies.
Yiwu Cold Knife Technique Versus Electrocision for Multiple Endometrial Polyps
Sponsor: The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Summary
\# Clinical Trial Summary Template (Based on your endometrial polyp study) The goal of this clinical trial is to learn if cold knife hysteroscopic polypectomy (Yiwu procedure) works to treat multiple endometrial polyps in women. It will also learn about the surgical safety of cold knife hysteroscopic polypectomy (Yiwu procedure). The main questions it aims to answer are: Does cold knife hysteroscopic polypectomy (Yiwu procedure) achieve a 1-year postoperative recurrence rate that is non-inferior to electroresection hysteroscopic polypectomy? What intraoperative and postoperative adverse events and complications do participants experience after receiving either surgical treatment? Researchers will compare cold knife hysteroscopic polypectomy (Yiwu procedure) to standard electroresection hysteroscopic polypectomy to verify whether the cold knife technique can reduce endometrial polyp recurrence without increasing surgical risks. Participants will: Receive either cold knife hysteroscopic polypectomy or conventional electroresection hysteroscopic polypectomy as standardized surgery Attend clinic follow-up visits at 3, 6 and 12 months after surgery for physical examinations and transvaginal ultrasound scans Complete clinical assessment records including menstrual status, abnormal uterine bleeding symptoms, pain conditions and patient satisfaction scores throughout the 1-year follow-up period
Official title: Non-inferiority Comparison of Cold Knife Hysteroscopy (Yiwu Technique) Versus Electrocision for the Treatment of Multiple Endometrial Polyps: A Prospective Multicenter Randomized Controlled Trial
Key Details
Gender
FEMALE
Age Range
20 Years - 48 Years
Study Type
INTERVENTIONAL
Enrollment
850
Start Date
2026-08-01
Completion Date
2029-06-01
Last Updated
2026-07-30
Healthy Volunteers
No
Interventions
Cold knife hysteroscopic polypectomy (Yiwu procedure)
Endometrial polyps are removed by mechanical cutting using hysteroscopic micro-scissors or morcellators. No electrosurgical energy is used for resection or hemostasis; bleeding control relies only on mechanical compression of the wound base. No thermal injury to surrounding endometrium is permitted during the operation.
Electroresection hysteroscopic polypectomy
Endometrial polyps are excised with standard hysteroscopic electrosurgical loops. High-frequency electric current is applied for tissue cutting and intraoperative hemostasis. Thermal ablation of normal endometrial tissue outside polyp lesions is prohibited per trial protocol.