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Mechanisms Underlying Late-Life Prolonged Grief Disorder
Sponsor: Medical College of Wisconsin
Summary
After losing a loved one, most successfully navigate acute grief and adapt to the loss within about 1 year, but in about 10%, prolonged grief disorder (PGD) ensues. This study is anticipated to provide novel evidence regarding the neurobiological mechanisms of PGD in older adults. The biological alterations identified here could provide targets to elucidate how currently available therapies work and inform novel mechanism-based interventions for treating late-life PGD.
Official title: Probing Brain Network Mechanisms Underlying Late-Life Prolonged Grief Disorder
Key Details
Gender
All
Age Range
40 Years - 89 Years
Study Type
INTERVENTIONAL
Enrollment
126
Start Date
2027-01
Completion Date
2031-06
Last Updated
2026-10-09
Healthy Volunteers
No
Conditions
Interventions
Iyengar Yoga
Participants will engage in 10 weekly IY classes
Health Education Control
Participants will engage in 10 weekly socialization control group sessions
Waitlist Control to Crossover
Upon Step 1 study completion (week 10), participants in this group who continue to meet PGD criteria on the SCIP will enter Step 2 phase
Locations (1)
Medical College of Wisconsin
Milwaukee, Wisconsin, United States