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NOT YET RECRUITING
NCT07741409
PHASE3

Povidone Iodine for Caries Prevention

Sponsor: Jeffrey A. Banas

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to learn if Povidone Iodine works to prevent tooth decay and suppress the mouth germs responsible for tooth decay. The main questions it aims to answer are: 1. How will home use of Povidone Iodine, as an adjunct treatment to standard dental care, reduce the incidence of tooth decay? 2. How will home use of Povidone Iodine reduce the mouth germs responsible for tooth decay? 3. If Povidone Iodine use is accompanied by probiotic use, will its effectiveness be even better than Povidone Iodine alone? Participants will: 1. Provide a plaque sample at the beginning of the study. 2. Swab their children's teeth once a week for one month and then monthly thereafter. Some participants may be asked to use probiotic drops nightly after brushing their teeth. 3. Keep a record of compliance. 4. Return every 6 months for a dental exam and to provide a plaque sample. Keep a diary of their symptoms and the number of times they use a rescue inhaler

Official title: Povidone Iodine to Prevent Early Childhood Caries

Key Details

Gender

All

Age Range

1 Year - 3 Years

Study Type

INTERVENTIONAL

Enrollment

174

Start Date

2026-08-03

Completion Date

2028-06-30

Last Updated

2026-08-03

Healthy Volunteers

Yes

Conditions

Interventions

DRUG

Povidone Iodine 5% Soln,Top,Kit

Home use of Povidone Iodine administered by swabbing teeth; weekly for the 1st month, monthly thereafter.

DIETARY_SUPPLEMENT

Probiotics

Home use of Povidone Iodine coupled with daily use of a probiotic.

DRUG

Placebo

Placebo for the Povidone Iodine

Locations (1)

University of Iowa College of Dentistry

Iowa City, Iowa, United States