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Optimal Timing of Staged Complete Revascularization in STEMI With Multivessel Disease
Sponsor: Chonnam National University Hospital
Summary
This prospective, multicenter, open-label, superiority trial will enroll patients with ST-segment elevation myocardial infarction (STEMI) and multivessel disease. Following successful percutaneous coronary intervention (PCI) of the infarct-related artery (IRA), patients who meet the eligibility criteria will be randomized in a 1:1 ratio to either in-hospital staged complete revascularization with PCI of non-IRA lesions performed on a separate day during hospitalization, at least 48 hours after PCI of the IRA, or out-of-hospital staged complete revascularization with PCI of non-IRA lesions performed after discharge between 15 and 45 days of randomization. In both groups, non-IRA lesions with 50-69% stenosis will be evaluated using FFR.
Official title: OPtimal TIming of Staged Complete RevascularizatiON in ST-Segment Elevation Myocardial Infarction With Multivessel Disease: The OPTION-STEMI2 Trial
Key Details
Gender
All
Age Range
19 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1252
Start Date
2026-09-01
Completion Date
2035-07-31
Last Updated
2026-08-17
Healthy Volunteers
No
Conditions
Interventions
In-hospital staged complete revascularization
PCI of non-IRA lesions will be performed on a separate day during the index hospitalization, at least 48 hours after PCI of the IRA. Non-IRA lesion which have equal or more than 70% diameter stenosis by visual estimation will be revascularized without FFR evaluation. Non-IRA lesion with diameter stenosis 50-69% by visual estimation will be evaluated using FFR device. In case of FFR value more than 0.8, non-IRA lesion will be deferred without PCI. If FFR value was equal or less than 0.8, non-IRA lesion will be revascularized.
Out-of-hospital staged complete revascularization
PCI of non-IRA lesions will be performed after discharge and between 15 and 45 days of randomization. Non-IRA lesion which have equal or more than 70% diameter stenosis by visual estimation will be revascularized without FFR evaluation. Non-IRA lesion with diameter stenosis 50-69% by visual estimation will be evaluated using FFR device. In case of FFR value more than 0.8, non-IRA lesion will be deferred without PCI. If FFR value was equal or less than 0.8, non-IRA lesion will be revascularized.
Locations (30)
Bucheon Sejong Hospital
Bucheon-si, South Korea
Gyeongsang National University Changwon Hospital
Changwon, South Korea
Samsung Changwon Medical Center
Changwon, South Korea
Soon Chun Hyang University Hospital Cheonan
Cheonan, South Korea
Chungbuk National University Hospital
Cheongju-si, South Korea
Kangwon National University Hospital
Chuncheon, South Korea
Daegu Catholic University Medical Center
Daegu, South Korea
Keimyung University Dongsan Hospital
Daegu, South Korea
Kyungpook National University Hospital
Daegu, South Korea
Yeongnam University Medical Center
Daegu, South Korea
Chungnam National University Hospital
Daejeon, South Korea
Chonnam National University Hospital
Gwangju, South Korea
Chosun University Hospital
Gwangju, South Korea
Gwangju Veterans Hospital
Gwangju, South Korea
Kwangju Christian Hospital
Gwangju, South Korea
Chung-Ang University Gwangmyeong Hospital
Gwangmyeong, South Korea
Jeju National University Hospital
Jeju City, South Korea
Jeonbuk National University Hospital
Jeonju, South Korea
Presbyterian Medical Center
Jeonju, South Korea
Gyeongsang National University Hospital
Jinju, South Korea
Inje University Busan Paik Hospital
Pusan, South Korea
Inje University Haeundae Paik Hospital
Pusan, South Korea
Kosin University Gospel Hospital
Pusan, South Korea
Pusan National University Hospital
Pusan, South Korea
Koera University Guro Hospital
Seoul, South Korea
Korea University Anam Hospital
Seoul, South Korea
Yonsei University Health System, Gangnam Severance Hospital
Seoul, South Korea
St. Carollo General Hospital
Suncheon, South Korea
Ajou University Hospital
Suwon, South Korea
Pusan National University Yangsan Hospital
Yangsan, South Korea