Clinical Research Directory

Inclusion Criteria: * Adult ≥ 18 years * Acute non-traumatic pain of moderate to severe intensity (VAS strictly greater than 39 mm) * Able to independently assess their pain using a VAS and to record it independently on paper. * Affiliated to a social security system * Having signed informed consent Exclusion Criteria: * Age \< 18 years * Contraindications to methoxyflurane as stated in the Summary of Product Characteristics: * Hypersensitivity to the active substance or to any other fluorinated anesthetic or to any excipient. * Malignant hyperthermia: known malignant hyperthermia or genetic predisposition. * History of serious adverse reactions (patient or relatives) after administration of inhaled anesthetics. * History of signs of liver injury after use of methoxyflurane or halogenated hydrocarbons. * Clinically significant renal impairment * Altered level of consciousness regardless of cause, including head trauma, drug or alcohol use * Clinical evidence of cardiovascular instability * Clinical evidence of respiratory depression * Hemodynamically unstable patient (SBP \< 100 mmHg, DBP \< 30 mmHg) * Patient having already received Methoxyflurane on the same day * Patient having taken analgesic treatment prior to emergency consultation within 4 hours of admission. * Pain ≤ 39 mm * Pregnant, breastfeeding. * Women of childbearing potential not using a highly effective method of contraception throughout the study. The absence of pregnancy must be confirmed by performing a pregnancy test. Patients who are unable to provide a urine sample at the time of inclusion will not be enrolled in the study. * Subject under legal protection * Patients currently within the exclusion period of another clinical trial.