Clinical Research Directory

Inclusion Criteria: * Acute ischemic stroke with moderate to severe hemiparesis * Functional independence in activities of daily living without requiring nursing care before the index stroke. * Consent process by participant or proxy, with reconsent provision. * Age ≥ 45 to ≤ 80 years of age (inclusive) on the date of randomization * Sufficient attention, comprehension, and cooperation to carry out instructions Exclusion Criteria: * Pre-existing motor deficit prior to index stroke * Posterior circulation ischemic stroke * Lacunar stroke * Qualifying brain imaging demonstrating intracranial hemorrhage, malignant middle cerebral artery (MCA) infarct with edema, or bilateral/multifocal infarcts, clinically significant vascular malformation, brain tumor, or other central nervous system (CNS) pathology * Recent major surgery or trauma (\<30 days)