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Implementation and Validation of an Analytical Protocol for Measuring de Novo Lipogenesis in the Liver Using Stable Isotopes
Sponsor: KU Leuven
Summary
During this study, an analytical protocol for measuring hepatic de novo lipogenesis (DNL) using deuterium oxide (²H₂O) will be implemented and validated in healthy participants.
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
10
Start Date
2025-08-25
Completion Date
2025-12-11
Last Updated
2026-08-03
Healthy Volunteers
Yes
Interventions
Deuterium oxide
Participants will orally consume 70% deuterium oxide (²H₂O), a non-radioactive stable isotope tracer, for 10 consecutive days. The total daily amount will be 100 mL on Days 1-4 and 50 mL on Days 5-10. The tracer will be used to label body water and newly synthesized palmitate for the measurement of fractional hepatic de novo lipogenesis and plasma-water ²H₂O washout.
Locations (1)
KU Leuven/ UZ Leuven
Leuven, Vlaams-Brabant, Belgium