Clinical Research Directory

Inclusion Criteria: * Patients aged 50 to 80 who are diagnosed with end-stage knee osteoarthritis that require unilateral primary total knee arthroplasty; * Patients who are determined by clinical and laboratory tests to have no absolute surgical contraindications; * Patients with good compliance, willing and able to undergo follow-up observations as required and sign the informed consent form; Exclusion Criteria: * Patients with a history of surgery on the affected knee joint in the past; * Patients with neuromuscular diseases; * Patients scheduled for knee joint replacement revision surgery; * Patients with active knee joint infection or systemic infection; * Patients who receive primary joint replacement due to non-knee osteoarthritis, such as rheumatoid arthritis, tuberculous arthritis, traumatic arthritis, etc; * Patients with valgus or varus deformity of the knee joint greater than 15°; * Patients with knee flexion deformity greater than 15°; * Patients whose heart and lung functions are determined by clinical and laboratory tests to be unable to tolerate surgery; * Patients with mental disorders who are unable to cooperate with treatment; * Patients who is lactating or pregnant; * Patients who are unwilling to participate in this study and did not sign the informed consent form; * Patients with poor compliance and inability to cooperate in completing the follow-up observers at critical times; * For any reason, the researchers believe that the subject is unlikely to complete this study.