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Comparison of PRF and Corticosteroids in Impacted Third Molar Surgery
Sponsor: Final International University
Summary
This prospective, randomized interventional study aims to compare the postoperative effects of standard treatment (control), platelet-rich fibrin (PRF), and PRF combined with corticosteroid treatment in patients undergoing impacted mandibular third molar surgery. A total of 60 participants will be randomly assigned to one of three treatment groups according to the study protocol. Postoperative pain, facial swelling, and trismus will be evaluated on postoperative days 1, 2, 3, and 7. The findings of this study are expected to provide evidence regarding the effectiveness of PRF alone and PRF combined with corticosteroid treatment in reducing postoperative complications following impacted mandibular third molar surgery.
Official title: Comparison of Postoperative Effects of PRF and Corticosteroid Treatments in Impacted Third Molar Surgery
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2024-09-03
Completion Date
2026-08
Last Updated
2026-08-03
Healthy Volunteers
Yes
Interventions
Platelet-rich fibrin (PRF)
Autologous platelet-rich fibrin (PRF) prepared from the participant's venous blood by centrifugation at 3000 rpm for 10 minutes, and then placed into the extraction socket immediately after impacted mandibular third molar surgery.
Dexamethasone
Dexamethasone (8 mg/2 mL) administered as a single intramuscular injection immediately after impacted mandibular third molar surgery in addition to platelet-rich fibrin (PRF), according to the study protocol.
Amoxicillin/Clavulanic Acid
Amoxicillin/clavulanic acid administered postoperatively according to the study protocol.
Paracetamol
Paracetamol 500 mg tablets administered postoperatively for pain control according to the study protocol.
Chlorhexidine
Chlorhexidine mouthwash administered postoperatively according to the study protocol.
Locations (1)
Final International University Faculty of Dentistry
Nicosia, Cyprus