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NOT YET RECRUITING
NCT07743086
PHASE1/PHASE2

Impact of Duffy-null Associated Neutropenia on Chemotherapy Dosing

Sponsor: Barbara Ann Karmanos Cancer Institute

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to: * In Phase 1 (observational) to develop an algorithm for treatment of Duffy-null positive patients for chemotherapy dosing * In Phase 2 (interventional), use the algorithm created in phase 1 to adjust chemotherapy dosing for Duffy-null patients

Official title: A Prospective Study of Duffy-null Associated Absolute Neutropenia and Its Impact on Chemotherapy Dosing

Key Details

Gender

All

Age Range

18 Years - 80 Years

Study Type

INTERVENTIONAL

Enrollment

886

Start Date

2026-09

Completion Date

2029-04-30

Last Updated

2026-08-03

Healthy Volunteers

No

Interventions

DRUG

Standard of Care chemotherapy Following an Algorithm

Standard of care chemotherapy for solid tumor malignancies with dose adjustment according to the algorithm produced in phase 1 for Duffy-null positive patients

DRUG

Standard of Care chemotherapy following CTCAE criteria

Standard of care chemotherapy for solid tumor malignancies with dose modifications and delays according to the standard of care using CTCAE criteria.

Locations (1)

Karmanos Cancer Institute

Detroit, Michigan, United States