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Impact of Duffy-null Associated Neutropenia on Chemotherapy Dosing
Sponsor: Barbara Ann Karmanos Cancer Institute
Summary
The goal of this clinical trial is to: * In Phase 1 (observational) to develop an algorithm for treatment of Duffy-null positive patients for chemotherapy dosing * In Phase 2 (interventional), use the algorithm created in phase 1 to adjust chemotherapy dosing for Duffy-null patients
Official title: A Prospective Study of Duffy-null Associated Absolute Neutropenia and Its Impact on Chemotherapy Dosing
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
886
Start Date
2026-09
Completion Date
2029-04-30
Last Updated
2026-08-03
Healthy Volunteers
No
Conditions
Interventions
Standard of Care chemotherapy Following an Algorithm
Standard of care chemotherapy for solid tumor malignancies with dose adjustment according to the algorithm produced in phase 1 for Duffy-null positive patients
Standard of Care chemotherapy following CTCAE criteria
Standard of care chemotherapy for solid tumor malignancies with dose modifications and delays according to the standard of care using CTCAE criteria.
Locations (1)
Karmanos Cancer Institute
Detroit, Michigan, United States