Clinical Research Directory

Inclusion Criteria: * Presence of culture positive fusarium fungal keratitis * Age over 18 years * Moderate to severe vision loss, defined as Snellen visual acuity of 20/40 (6/12) to 20/400 (6/120) * Corneal thickness ≥350 µm, as measured on AS-OCT * Basic understanding of the study as determined by the physician * Commitment to return for follow up visits Exclusion Criteria: * History of hypersensitivity to Rose Bengal * Evidence of concomitant infection on exam, gram stain, or confocal microscopy (i.e. herpes, both bacteria and acanthamoeba on gram stain) * History of intraocular surgery within the last three months\* * Impending or frank perforation at recruitment * Involvement of sclera at presentation * Presence of desmetocele at recruitment * Non-infectious or autoimmune keratitis * History of corneal transplantation * Pinhole visual acuity worse than 20/200 in the unaffected eye * Participants who are decisionally and/or cognitively impaired