Clinical Research Directory

Inclusion Criteria: 1. A physician-diagnosed SCA3 according to diagnostic criteria, with definite clinical symptoms and confirmed genetic testing; 2. Age 18-75 years; 3. Baseline total score of SARA: 8-30 points (inclusive); SARA gait function subscore: 2-6 points (inclusive); 4. Willing to participate and provide informed consent; 5. Have a reliable caregiver available; 6. No severe cognitive impairment that would preclude reliable reporting of adverse events or efficacy during treatment. Exclusion Criteria: 1. History of seizures or convulsions, or a seizure within 6 months prior to enrolment; 2. History of severe traumatic brain injury or intracranial neurosurgery; 3. Presence of cardiac pacemakers, cochlear implants, intracranial implanted electronic devices, or other MRI-contraindicated ferromagnetic implants; 4. Severe cognitive impairment (Mini-Mental State Examination \[MMSE\] score ≤ 9) or severe visual, auditory, or speech dysfunction preventing cooperation with scale assessments and study procedures; 5. Pregnant or lactating women, or women of childbearing age not using reliable contraception; 6. Previous neuromodulation treatment (e.g., rTMS or tDCS) within the past year; 7. Skin breakdown or inflammation at the electrode placement site, or known allergy to conductive gel or electrode patch adhesives; 8. Currently participating in other interventional clinical trials, or planning to participate in other trials that might affect the outcome assessment of this study during the study period.