Clinical Research Directory
Browse clinical research sites, groups, and studies.
Validation of Serum Metabolite Differences in Patients With Gallstones and Gallbladder Cancer
Sponsor: Centre Paul Strauss
Summary
We have observed that the serum levels of certain metabolites differ between Chilean patients with gallbladder cancer and those with gallstone disease. Based on these discovery results, we selected ten candidate metabolites based on the smallest p-values among metabolites exhibiting a fold-change greater than 1.5. The aim of the present study is to validate these ten differential metabolite levels in an independent cohort of Chilean patients with gallbladder cancer and gallstone disease, and to assess the transferability of these findings to other patient populations.
Official title: Validation of Differential Serum Levels of Ten Candidate Metabolites in Gallstone Patients With and Without Gallbladder Cancer
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
230
Start Date
2019-12-01
Completion Date
2026-01-31
Last Updated
2026-08-04
Healthy Volunteers
No
Interventions
serum samples
serum samples
Locations (33)
Complejo Hospitalario Viedma
Cochabamba, Bolivia
Hospital del Norte
Cochabamba, Bolivia
Hospital Obrero No. 2 (Caja Nacional del Seguro Social)
Cochabamba, Bolivia
Instituto Gastroenterológico
Cochabamba, Bolivia
Instituto Oncológico Nacional
Cochabamba, Bolivia
Hospital Clínico de Magallanes
Arica, Chile
Hospital Regional de Arica
Arica, Chile
Hospital Regional de Concepción,
Concepción, Chile
Hospital De Puerto Montt
Port Montt, Chile
Hospital Regional de Rancagua
Rancagua, Chile
Clínica Alemana de Santiago
Santiago, Chile
Fundación Arturo López Perez (FALP)
Santiago, Chile
Hospital Barros Luco
Santiago, Chile
Hospital Clínico Universidad de Chile
Santiago, Chile
Hospital del Salvador
Santiago, Chile
Hospital El Pino
Santiago, Chile
Hospital Padre Hurtado
Santiago, Chile
Hospital San Borja
Santiago, Chile
Hospital San Juan de Dios
Santiago, Chile
Hospital Sótero del Río
Santiago, Chile
Hospital Regional de Talca
Talca, Chile
Clínica Alemana de Temuco
Temuco, Chile
Complejo Asistencial Padre Las Casas
Temuco, Chile
Hospital Regional de Temuco
Temuco, Chile
Statistical Genetics Research Group, Institute of Medical Biometry, University of Heidelberg
Heidelberg, Germany
Hospital Goyoneche
Arequipa, Peru
Hospital Honorio Delgado
Arequipa, Peru
Instituto Regional de Enfermedades Neoplásicas del Sur (IREN Sur)
Arequipa, Peru
Clínica Monte Sinaí
Juliaca, Peru
Hospital Base III- La Capilla ESSALUD
Juliaca, Peru
Instituto Nacional de Enfermedades Neoplásicas (INEN)
Lima, Peru
Hospital Regional Manuel Nuñez Butrón
Puno, Peru
Instituto Regional de Enfermedades Neoplásicas del Norte (IREN Norte)
Trujillo, Peru