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Efficacy of Negative Pressure Wound Therapy Versus Conventional Moist Dressings on Diabetic Foot Ulcer Healing Trajectories
Sponsor: Jerash Private University
Summary
Background: Diabetic foot ulcers (DFUs) are severe, chronic complications of diabetes carrying a high risk of amputation. While Negative Pressure Wound Therapy (NPWT) is an active biophysical treatment, clinical evidence using multidimensional tools in Middle Eastern settings like Jordan has been limited. Methods: A 3-month randomized controlled trial (January-May 2026) was conducted at the National Center for Diabetes, Endocrinology, and Genetics (NCDEG) in Amman, Jordan, involving 60 patients with chronic DFUs. Participants were randomized to either an intervention group receiving NPWT (80-125 mmHg, changed every 4 days) or a control group receiving conventional moist dressings (changed every 2 days). Wound trajectories were assessed using the 13-item Bates-Jensen Wound Assessment Tool (BWAT©).
Official title: Efficacy of Negative Pressure Wound Therapy Versus Conventional Moist Dressings on Diabetic Foot Ulcer Healing Trajectories: A Randomized Controlled Trial Evaluating Clinical and Biophysical Outcomes
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2026-01-01
Completion Date
2026-05-01
Last Updated
2026-08-04
Healthy Volunteers
Yes
Conditions
Interventions
Vacuum-Assisted Closure (VAC / NPWT)
Vacuum-Assisted Closure (VAC / NPWT) Following initial surgical debridement in the operating room, a sterile foam dressing was applied to the wound bed under aseptic conditions and secured with an adhesive drape to establish an airtight seal. An evacuation tube embedded within the foam was connected to a vacuum unit, delivering continuous sub-atmospheric negative pressure ranging between 80 and 125 mmHg for 96 hours. Exudate was continuously collected into a sealed canister, transforming open ulcerations into controlled, closed, moist healing environments. Dressings were routinely changed under sterile conditions every 4 days during the inpatient stay.
Locations (1)
the National Center for Diabetes, Endocrinology, and Genetics (NCDEG)
Amman, Dours, Jordan