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Research On Advanced Diagnostics and Management of All Pregnancies to Prevent Stillbirth (ROADMAPS)
Sponsor: RTI International
Summary
The primary objective of the Stillbirth Research Consortium (SBRC) longitudinal cohort study is to develop and evaluate a robust multivariable prediction model to identify pregnancies at \<14 weeks gestation that are at increased risk of stillbirth or fetal growth restriction (FGR), often reflecting underlying placental dysfunction. Secondary objectives include: * To evaluate placental pathology among cases and selected controls using standardized Amsterdam criteria. * To identify key aspects of perinatal nutrition contributing to placental dysfunction * To determine relationships between maternal biomarkers, placental pathology and energetics, with the goal of identifying biomarkers predictive of placental dysfunction * To develop a risk stratification model for pregnancies complicated by decreased fetal movements (DFM)
Official title: NICHD Stillbirth Research Consortium: Research on Advanced Diagnostics and Management of All Pregnancies to Prevent Stillbirth (ROADMAPS)
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
7000
Start Date
2026-08-01
Completion Date
2030-07-31
Last Updated
2026-08-04
Healthy Volunteers
Yes
Conditions
Locations (5)
University of California Center for Stillbirth Prevention
San Diego, California, United States
The Collaborative Action for Research to End Stillbirth (CARES) Research Center at Columbia University
New York, New York, United States
Oregon Health & Science University
Portland, Oregon, United States
University of Utah
Salt Lake City, Utah, United States
Old Dominion University
Norfolk, Virginia, United States