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Low Dose Aspirin vs Placebo in Prevention of Recurrent Spontaneous Preterm Labour
Sponsor: University of Health Sciences Lahore
Summary
Abnormal Uterine Bleeding (AUB) is a common gynecological issue affecting women globally, requiring endometrial tissue sampling to evaluate underlying causes such as hyperplasia, polyps, or malignancy. While Pipelle biopsy is a widely used outpatient sampling technique, its single-use nature makes it relatively expensive in resource-limited settings. Manual Vacuum Aspiration (MVA) using a 4 mm flexible cannula is an inexpensive, reusable alternative that requires no cervical dilation or electricity, but direct comparative evidence between MVA and Pipelle remains limited
Official title: Comparison of Low Dose Aspirin vs Placebo in the Prevention of Recurrent Spontaneous Preterm Labou
Key Details
Gender
FEMALE
Age Range
35 Years - Any
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2026-08-20
Completion Date
2027-08-15
Last Updated
2026-08-04
Healthy Volunteers
No
Interventions
Manual Vacuum Aspiration (MVA) Cannula
Endometrial sampling performed using a 4 mm flexible polyethylene Manual Vacuum Aspiration (MVA) cannula attached to a double-valve MVA syringe. The procedure is conducted in an outpatient setting under aseptic conditions without local anesthesia or cervical dilation.
Pipelle Endometrial Suction Curette
Endometrial biopsy performed using a standard flexible Pipelle device. The sheath is introduced through the cervix, and the internal piston is withdrawn to create negative pressure suction while rotating the sheath 360 degrees to sample the uterine cavity, performed without local anesthesia or cervical dilation.