Clinical Research Directory

Inclusion Criteria: 1. Age: ≥ 18 years. 2. Good general health. Need for extraction of incisors, canines, or premolars due to caries, endodontic complications, root fracture, or prosthetic reasons. 3. Presence of three intact alveolar walls following tooth extraction, with a defect in the vestibular wall (\<50%). 4. Need for treatment with single-tooth implants, with adjacent teeth and occlusal antagonists present. 5. Sufficient available bone, as assessed by CBCT, for the placement of implants 3.6 mm in diameter and 10 mm in length. 6. Periodontal health with intact or reduced periodontium. Full-mouth plaque and bleeding scores \< 20%. 7. Ability and willingness to follow the study procedures and instructions. Exclusion Criteria: 1. Compromised health status. Presence of any systemic condition, such as uncontrolled diabetes mellitus, cancer, HIV, disorders that impair wound healing, chronic high-dose steroid therapy, intravenous and oral bisphosphonate therapy, metabolic bone diseases, a history of head and neck radiation, or any other immunosuppressive therapy that contraindicates oral surgical treatment. 2. Absence of adjacent teeth or opposing occlusal teeth. 3. The missing tooth is a molar. 4. More than one defect in the bone wall or a buccal defect \>50%. 5. Allergy or hypersensitivity to medications or any product used during the study. 6. Regular use of tobacco (defined as \>1 cigarette per day) or chewing tobacco, even within the 3 months prior to enrollment. 7. Untreated periodontitis. 8. Acute periapical or periodontal infection. 9. Oral plaque and/or bleeding \> 20%.