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Benzydamine vs Supersaturated Calcium Phosphate Oral Rinses for Radiation Induced Oral Mucositis in Head and Neck Cancer Patients.
Sponsor: Postgraduate Medical Institute, Lahore
Summary
The goal of this clinical trial is to compare and correlate salivary macrophage migratory inhibitory factor levels with onset and severity of radiation induced mucositis in head and neck cancer patients by using super saturated calcium phosphate solution and benzydamine hydrochloride oral rinses. Participants are patients of head and neck cancers undergoing radiation therapy of either gender. participants are divided into two groups Group A: Benzydamine group Group B: Super saturated calcium phosphate group * Participants will be using Oral rinses of their respective group and will be assessed for radiation induced oral mucositis at weekly intervals during radiation treatment. * salivary Macrophage migratory inhibitory factor levels will be assessed through ELISA, before and after the radiation treatment as per protocol.
Official title: COMPARISON Between TWO MOUTHWASHES in the Prevention and Management of ORAL MUCOSITIS During RADIOTHERAPY of HEAD AND NECK CANCER Patients.
Key Details
Gender
All
Age Range
30 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
42
Start Date
2022-04-13
Completion Date
2023-04-30
Last Updated
2026-08-05
Healthy Volunteers
No
Conditions
Interventions
Benzydamine hydrochloride mouthrinse
Comparison of Salivary macrophage migratory inhibitory factor through ELISA in both the intervention groups and observing onset and severity of oral mucositis in both groups
Super saturated calcium phosphate oral rinses
salivary Macrophage migratory inhibitory factors will be assessed before and after radiation therapy
Locations (1)
Post Graduate Medical Institute, Lahore.
Lahore, Punjab Province, Pakistan