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Effect of Titanium-Prepared Platelet-Rich Fibrin and Low-Level Laser Therapy on Postoperative Morbidity After Mandibular Third Molar Surgery
Sponsor: NEW Cyprus Health and Social Sciences University
Summary
This randomized double-blind clinical trial aims to evaluate the effects of titanium-prepared platelet-rich fibrin (T-PRF), low-level laser therapy (LLLT), and their combination on postoperative outcomes following surgical extraction of impacted mandibular third molars. Sixty patients will be randomly allocated to one of four parallel groups: T-PRF, LLLT, T-PRF plus LLLT, or control. The primary outcomes include postoperative pain assessed using a visual analogue scale (VAS), analgesic consumption, postoperative swelling and trismus. The findings may help identify effective approaches for improving postoperative recovery after mandibular third molar surgery.
Official title: Effects of Titanium-Prepared Platelet-Rich Fibrin and Low-Level Laser Therapy on Postoperative Pain, Swelling, Trismus, and Analgesic Consumption Following Mandibular Third Molar Surgery: A Randomized Double-Blind Clinical Trial
Key Details
Gender
All
Age Range
18 Years - 31 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2025-12-27
Completion Date
2026-06-29
Last Updated
2026-08-05
Healthy Volunteers
Yes
Interventions
Titanium-Prepared Platelet-Rich Fibrin (T-PRF)
Titanium-prepared platelet-rich fibrin (T-PRF) was prepared from autologous blood and placed into the extraction socket immediately after mandibular third molar surgery.
Low-Level Laser Therapy (LLLT)
Low-level laser therapy was applied using a 650 nm diode laser (25 mW) immediately after surgery and once daily for the following two postoperative days.
Locations (1)
Cyprus Health and Social Sciences University, Faculty of Dentistry
Güzelyurt, Güzelyurt, Turkey (Türkiye)