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Pneumococcal Carriage Duration
Sponsor: University of Central Florida
Summary
Streptococcus pneumoniae (SPN) remains a leading cause of respiratory disease in young children despite widespread vaccination. Understanding the duration of pneumococcal carriage, patterns of co-colonization, and the influence of viral infections and the respiratory microbiome is essential to evaluate next-generation pneumococcal vaccines and inform public health strategies. Current data on Streptococcus pneumoniae carriage dynamics are limited in U.S. pediatric populations. This study aims to generate updated estimates of Streptococcus pneumoniae colonization and explore microbial interactions using high-resolution longitudinal sampling and genomic methods.
Official title: NIS103487 Duration of Streptococcus Pneumoniae Carriage in U.S. Children Under Five: A Pilot Longitudinal Study
Key Details
Gender
All
Age Range
28 Days - 48 Months
Study Type
OBSERVATIONAL
Enrollment
60
Start Date
2026-07-21
Completion Date
2027-07
Last Updated
2026-08-06
Healthy Volunteers
Yes
Conditions
Interventions
Oropharyngeal (OP) swab
At each study visit, a double-tipped OP swab will be collected by trained clinical research staff. All swabs will be collected using a standard protocol. There will be 26 total study visits over the course of one year.
Locations (1)
University of Central Florida
Orlando, Florida, United States