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Correlation Between MRI Findings and Clinical Improvement Following TMJ Injection With Hyaluronic Acid and Platelet-Rich Plasma
Sponsor: Mansoura University
Summary
Temporomandibular joint (TMJ) disorders can cause jaw pain, clicking sounds, and difficulty opening the mouth, affecting daily activities such as eating and speaking. This study aims to determine whether magnetic resonance imaging (MRI) findings can help predict how much patients improve after a single injection into the TMJ containing hyaluronic acid and platelet-rich plasma (PRP). Adults with TMJ internal derangement who have not improved with conservative treatment will receive one injection of hyaluronic acid combined with PRP prepared from their own blood. Participants will be evaluated before treatment and at follow-up visits over 6 months. Assessments will include pain, jaw function, mouth opening, and MRI scans before and after treatment. The results of this study may improve understanding of the relationship between MRI findings and treatment outcomes and help healthcare providers identify patients who are most likely to benefit from this minimally invasive therapy.
Key Details
Gender
All
Age Range
18 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2025-04-01
Completion Date
2026-04-12
Last Updated
2026-08-06
Healthy Volunteers
No
Conditions
Interventions
intra-articular Injection of Hyaluronic Acid Combined with Platelet-Rich Plasma
Platelet-rich plasma (PRP) will be prepared from 10 mL of the participant's peripheral venous blood using centrifugation. One milliliter of PRP will be mixed with 1 mL of hyaluronic acid and administered as a single intra-articular injection into the affected temporomandibular joint under aseptic conditions. Clinical outcomes (pain intensity, joint clicking, and maximum interincisal opening) will be evaluated at baseline and at 1 week, 1 month, 3 months, and 6 months after treatment. MRI examinations will be performed before treatment and at the 6-month follow-up to assess the relationship between MRI findings and clinical improvement.
Locations (1)
Faculty of Dentistry, Mansoura University
Al Mansurah, Dakahlia Governorate, Egypt