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Hyaluronic Acid vs I-PRF With Microneedling in Enhancing Peri-implant Soft Tissue
Sponsor: Ain Shams University
Summary
This study aims to compare the use of microneedling alone versus with hyaluronic acid or i-PRF in conjunction with microneedling in peri-implant mucosa in the esthetic zone to test the superior increase in gingival thickness.
Official title: Hyaluronic Acid Versus I-PRF Combined With Microneedling for Peri Implant Soft Tissue Enhancement: A Randomized Controlled Clinical Trial
Key Details
Gender
All
Age Range
21 Years - 50 Years
Study Type
INTERVENTIONAL
Enrollment
42
Start Date
2026-10-30
Completion Date
2028-05-30
Last Updated
2026-08-06
Healthy Volunteers
No
Conditions
Interventions
Hyaluronic Acid (HA)
Hyaluronic acid (HA) is a genuine linear glycosaminoglycan that is present within the extracellular matrix of connective, epithelial, and neural tissues.
Platelet rich fibrin
Injectable PRF (i-PRF) is a notable method in enhancing soft tissue phenotypes, relying on its injectable form that can be well delivered to targeted areas to ensure proper distribution of growth factors and cytokines.