Clinical Research Directory

Inclusion Criteria: * Meets the diagnostic criteria for Chronic Obstructive Pulmonary Disease (COPD) with confirmed persistent airflow limitation by spirometry. * Hospitalized due to an acute exacerbation of COPD. * Stable daytime arterial blood gas analysis showing PaCO₂ ≥ 50 mmHg, with hypoxemia. * Already receiving or planned to receive long-term home non-invasive respiratory support. * Capable of using a smartphone or tablet for video communication and has internet access. * Willing to participate and provides written informed consent. Exclusion Criteria: * Concurrent severe pulmonary diseases (e.g., active tuberculosis, diffuse pulmonary fibrosis, advanced lung cancer). * Chronic respiratory failure primarily caused by non-COPD conditions (e.g., neuromuscular disease, chest wall deformity, or severe obesity hypoventilation syndrome). * Severe cognitive impairment or psychiatric illness that would prevent cooperation with remote management. * Other severe systemic diseases with an expected survival of less than 1 year (e.g., advanced malignancy). * Pregnant or lactating women.