Clinical Research Directory

Inclusion Criteria: * Men and women, aged between 40-75 years * Pre-diabetes: (A1C of 5.7%-6.4%, a fasting plasma glucose (FPG) of 100-125 mg/dL, or a 2-hour oral glucose tolerance test (OGTT) result of 140-199 mg/dL) * BMI ³ 25 kg/m2 * Fasting serum total cholesterol \< 8.0 mmol/L * Systolic blood pressure \< 160 mmHg and diastolic blood pressure \< 100 mmHg * Willingness to give up being a blood donor from 8 weeks before the start of the study, during the study and for 4 weeks after completion of the study Exclusion Criteria: * Age less than 40 years old or older than 75 years * BMI \< 25 kg/m2 * Type 1 or type 2 diabetes * habitual consumption of more than 1 avocado/ week * Left-handedness * Fasting serum total cholesterol \> 8.0 mmol/L * Current smoker, or smoking cessation \< 12 months * Abuse of drugs * More than 3 alcoholic consumptions per day * Use medication to treat blood pressure, lipid or glucose metabolism * Use of an investigational product within another biomedical intervention trial within the previous 1-month * Severe medical conditions that might interfere with the study, such as epilepsy, asthma, kidney failure or renal insufficiency, chronic obstructive pulmonary disease, inflammatory bowel diseases, auto inflammatory diseases and rheumatoid arthritis * Active cardiovascular disease like congestive heart failure or cardiovascular event, such as an acute myocardial infarction or cerebrovascular accident * Contra-indications for MRI imaging (e.g. pacemaker, surgical clips/material in body, metal splinter in eye, claustrophobia) * Blood donation in the 8 weeks before the start of the study * Difficulties to draw blood