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Effects of Curcumin-Piperine Supplementation in Fibromyalgia
Sponsor: Ain Shams University
Summary
The goal of this clinical trail is to evaluate the effectiveness and safety of curcumin-piperine supplementation in patients with fibromyalgia over 3 months compared to placebo. Participants will: Be randomly assigned to receive either curcumin and piperine supplements or a placebo. Attend scheduled clinic visits for clinical assessments and blood sample collection. Complete study questionnaires before and after treatment time frame. The primary question the study aim to answer is: Does Curcumin-piperine supplementation reduce pain intensity by Visual Analog Scale (VAS), compared with placebo? The secondary questions this study aims to answer are: Does supplementation improve fibromyalgia disease impact and quality of life? Does supplementation improve inflammatory biomarkers and oxidative stress? Does supplementation improve insulin resistance? Is curcumin and piperine supplementation safe and well tolerated?
Official title: Evaluation of the Effect of Curcumin and Piperine Supplementation on Clinical Outcome in Fibromyalgia Patients.
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2026-08-01
Completion Date
2027-08-01
Last Updated
2026-08-11
Healthy Volunteers
No
Conditions
Interventions
Curcumin - Piperine
The experimental group will receive Organic Nation Curcumin® oral coated tablets, administered once daily for 3 months, containing 1,200 mg of standardized curcumin (95% turmeric extract) combined with 10 mg of piperine (95% black pepper extract).
Placebo
the placebo group will receive matching oral placebo tablet containing inert excipients for the same duration. The placebo tablets will be identical in appearance, size, color, and packaging to the active supplement to maintain blinding.
Locations (1)
Suez Canal University hospitals
Ismailia, Egypt