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Effect of Oral Isotretinoin on Ocular Surface and Meibomian Glands
Sponsor: Benha University
Summary
The aim of the study was to evaluate meibomian gland morphology using non-contact meibography and ocular surface changes in patients with acne vulgaris treated with isotretinoin as indicators of dry eye, which is known to be a side effect of isotretinoin.
Official title: Assessment of the Effect of Oral Isotretinoin for Acne Treatment on the Ocular Surface and the Morphology of the Meibomian Gland
Key Details
Gender
All
Age Range
Any - Any
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2024-01-01
Completion Date
2025-06-30
Last Updated
2026-08-10
Healthy Volunteers
Yes
Interventions
isotretinoin
1. Meibomian Gland Morphology (Meiboscore) 2. Ocular Surface Disease Index (OSDI) Score 3. Invasive Tear Film Break-Up Time (ITF-BUT) 4. Schirmer II Test 5. Ocular Surface Staining (Oxford Scale) 6. Meibum Expressibility Score (MES) 7. Eyelid Score 8. Non-Invasive Tear Film Break-Up Time (NIF-BUT) time frame: at baseline and 6 months after isotretinoin therapy
Locations (1)
faculty of Medicine
Banhā, Egypt