Clinical Research Directory

Inclusion Criteria: * History of subacute moderate-to-severe brain injury resulting in a new functional impairment, as defined by: Glasgow Coma Scale score (GCS) \< 13 points * Subacute brain injury is defined to be \< 3 months since index injury Exclusion Criteria: * Weight \< 25 kg * History pre-existing chronic kidney disease (CKD stage ≥ 2), prior kidney transplantation, previous dialysis dependence, or solitary kidney status * Premorbid (pre-brain injury) eGFR \< 60 * Inability to obtain regular phlebotomy for any reason * Known inborn errors of mitochondrial function * Premorbid history of significant head trauma or brain injury requiring hospitalization * Pregnancy * Concurrent malignancy * Any other current, serious, chronic medical or psychiatric disease that in the PI's judgment may interfere with study participation or data integrity