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Dynamics of Wound Healing in Patients With Obesity
Sponsor: University of Iowa
Summary
Healing after dental surgery can vary from person to person. This study is being done to understand how body weight (obesity vs. normal weight) may affect healing after tissue is removed from the roof of the mouth during a gum graft procedure. The study will also evaluate whether a healing material made from a participant's own blood, called platelet-rich fibrin (PRF), is comparable in quantity and quality to the standard-of-care collagen plug. First, participants will be classified into obese or normal weight groups. Next, participants will be randomized to receive either collagen plug or platelet-rich fibrin clot during their surgical procedure Then, participants will return for 4 visits up to 30 days from the surgery visit.
Official title: Temporal Dynamics of Palatal Wound Healing With and Without Adjunctive Biologics in Patients With Obesity
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
104
Start Date
2026-08
Completion Date
2029-08
Last Updated
2026-08-10
Healthy Volunteers
No
Conditions
Interventions
Collagen Plug (standard of care)
Collagen Plug (standard of care)
Platelet-Rich Fibrin Clot
Platelet-Rich Fibrin Clot is placed on wound
Locations (1)
University of Iowa College of Dentistry and Dental Clinics
Iowa City, Iowa, United States