Clinical Research Directory

Inclusion Criteria: * adult patients \>/= 18 years of age admitted to an intensive care unit * Diagnosed clinically with Society for Cardiovascular Angiography and Interventions (SCAI) Class C or D cardiogenic shock * Clinical or hemodynamic evidence of volume overload Exclusion Criteria: * Patients whose care plan, as determined by the treating clinical team, will not include renal replacement therapy * Decision has already been made by the treating clinical team to initiate renal replacement therapy * Hyperkalemia with serum potassium \>/= 6mmol/L at the time of screening * Severe metabolic acidosis with serum bicarbonate \</= 12 mmol/L at the time of screening * Severe azotemia with serum urea \>/= 40 mmol/L at the time of screening * Acute intoxication necessitating use of renal replacement therapy * Recent renal replacement therapy (within 30 days) * Known end-stage renal disease (defined as an estimated glomerular filtration rate \<15 ml/min/1.73m2 * presentation with out-of-hospital cardiac arrest