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Implementation of New Models of Ovarian Carcinoma Resistant to Therapy
Sponsor: Mario Negri Institute for Pharmacological Research
Summary
The project focuses on developing new experimental models of ovarian cancer that accurately reflect patients who do not respond to first-line platinum-based treatments and who are resistant to PARP inhibitors (PARPi). These models are essential for testing new drugs or drug combinations in preclinical settings that closely mimic real clinical conditions. These models will also help to identify predictive biomarkers of treatment response and to better understand the biological mechanisms behind therapy resistance.
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
50
Start Date
2026-08-01
Completion Date
2036-08-31
Last Updated
2026-08-11
Healthy Volunteers
No
Conditions
Interventions
Platinum drugs and PARPi
Patients with ovarian carcinoma resistant to platinum drugs and PARPi undergoing paracentasis and/or surgical with left-over tumor material.