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Letrozole High Dose (10 mg) Compared to Letrozole Low Dose( 5 mg) for Ovarian Stimulation in Infertile Women With Polycystic Ovary Syndrome
Sponsor: Mst.Sumyara Khatun
Summary
The goal of this clinical trial is to learn if drug letrozole 10mg for 5 days works better than letrozole 5mg for 5 days for ovarian stimulation in infertile women with PCOS. It will also learn about the safety of drug letrozole . The main questions it aims to answer are: What medical problems do participants have when taking drug letrozole? Researchers will compare drug letrozole 10mg for 5 days works better than letrozole 5 mg for 5 days for ovarian stimulation in infertile women with PCOS Participants will: The experimental arm (p1) will be treated with letrozole 10 mg for 5 days. The comparator arm (p2) will receive letrozole 5 mg for 5 days for ovulation induction for consecutive 3 months Treatment will start from the 2nd day of menstruation cycle or withdrawal bleeding after the baseline visit and investigations. Ovarian response will be assessed by trans-vaginal monitoring of follicle growth around day 10 of menstrual cycle
Key Details
Gender
FEMALE
Age Range
18 Years - 35 Years
Study Type
INTERVENTIONAL
Enrollment
86
Start Date
2025-02-01
Completion Date
2026-02-01
Last Updated
2026-08-12
Healthy Volunteers
No
Conditions
Interventions
Tab.Letrozole 10 mg for 5 days
Tablet letrozole 10mg for 5 days from day 2-3 of enstruation/withdrawal bleeding (10mg in divided dose-5mg in morning \& 5mg at bed time for 5 days) for three months
Tab.Letrozole 5mg for 5 days
Tab letrozole 5mg for 5 days from day 2-3 ofenstruation/withdrawal bleeding (5mg at bed time for 5 days) for three months.
Locations (1)
Bangladesh Medical University
Dhaka, Bangladesh