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Effect of Intrauterine Insemination on Subsequent Pregnancy Outcomes in Couples With Unexplained Pregnancy Loss: A Multicenter, Open-label, Randomized Controlled Trial
Sponsor: Lanzhou University Second Hospital
Summary
Unexplained pregnancy loss remains a major reproductive challenge, and effective management strategies for affected couples are limited. Although intrauterine insemination (IUI) is widely used in reproductive medicine, its effectiveness in improving subsequent pregnancy outcomes among couples with unexplained pregnancy loss has not been well established. This multicenter, open-label, randomized controlled trial aims to evaluate whether IUI improves subsequent pregnancy outcomes compared with natural conception in couples with unexplained pregnancy loss. A total of 558 eligible couples will be enrolled and randomly assigned to either an IUI group or a natural conception group. Participants will be followed to assess reproductive outcomes. The findings of this study are expected to provide high-quality evidence regarding the role of IUI in the management of unexplained pregnancy loss and to inform future clinical practice.
Key Details
Gender
FEMALE
Age Range
20 Years - 37 Years
Study Type
INTERVENTIONAL
Enrollment
558
Start Date
2026-01-27
Completion Date
2027-12-31
Last Updated
2026-08-12
Healthy Volunteers
No
Conditions
Interventions
Intrauterine Insemination (IUI)
Participants assigned to the intervention group undergo intrauterine insemination (IUI) according to the study protocol. Processed sperm is placed into the uterine cavity during the periovulatory period to improve the likelihood of conception.
Locations (3)
Beijing Amcare Beisanhuan Women's & Children's Hospital
Beijing, Beijing Municipality, China
Lanzhou university second hosipital
Lanzhou, Gansu, China
Hebei Reproductive Health Hospital
Shijiazhuang, Hebei, China