Clinical Research Directory

Inclusion Criteria: * Age ≥18 years and ≤90 years * First-time admission to the Intensive Care Unit (ICU) * Diagnosis of sepsis according to Sepsis-3.0 criteria (documented or clinically suspected infection plus Sequential Organ Failure Assessment \[SOFA\] score ≥2 points) * Expected ICU survival time ≥24 hours * Written informed consent provided by the patient or legal surrogate Exclusion Criteria: * Pregnancy or lactation * Cardiopulmonary-cerebral resuscitation (CPCR) performed during the current hospital admission * Pre-existing primary central nervous system (CNS) diseases, including: Acute cerebrovascular disease (e.g., hemiplegia, cranial nerve palsy) Central nervous system infection (e.g., pleocytosis in cerebrospinal fluid) Organic or metabolic encephalopathy (e.g., hepatic, renal, pulmonary, pancreatic, or severe inherited metabolic disorders) Drug-related encephalopathy (e.g., antipsychotic-associated encephalopathy, serotonin syndrome, neurotoxic antibiotics) Other structural or immunological brain diseases (e.g., traumatic brain injury, intracranial neoplasm, autoimmune encephalopathy) \- Inability to cooperate with or tolerate scalp EEG electrode placement (e.g., extensive scalp trauma or open scalp infection)