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A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF
Sponsor: AstraZeneca
Summary
This is a Phase III, randomized, double-blind, parallel-group, placebo-controlled, multicenter study to investigate CV outcomes with elecoglipron compared with placebo, in adults with heart failure with preserved ejection fraction (HFpEF)/heart failure with mildly reduced ejection fraction (HFmrEF), irrespective of T2DM status, and who are on background dapagliflozin in addition to other background standard of care.
Official title: A Phase III, Randomized, Double-blind, Parallel-group, Placebo-controlled, Multicenter Study to Evaluate the Effect of Elecoglipron in Reducing Cardiovascular Outcomes in Participants With HFpEF and HFmrEF (Elevate-HF)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
6950
Start Date
2026-08-24
Completion Date
2029-09-03
Last Updated
2026-09-28
Healthy Volunteers
No
Conditions
Interventions
Elecoglipron
Elecoglipron tablet
Placebo
Placebo tablet
Locations (679)
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Fairhope, Alabama, United States
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Anchorage, Alaska, United States
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Gilbert, Arizona, United States
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Sun City, Arizona, United States
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Beverly Hills, California, United States
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Huntington Beach, California, United States
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Huntington Park, California, United States
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Loma Linda, California, United States
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Lomita, California, United States
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Mather, California, United States
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Northridge, California, United States
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Palo Alto, California, United States
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Redding, California, United States
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San Diego, California, United States
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Tarzana, California, United States
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Colorado Springs, Colorado, United States
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New Haven, Connecticut, United States
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Bradenton, Florida, United States
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Hallandale, Florida, United States
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Jacksonville, Florida, United States
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Lakeland, Florida, United States
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Miami, Florida, United States
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Miami, Florida, United States
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Miami, Florida, United States
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Miami Lakes, Florida, United States
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Miami Lakes, Florida, United States
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Ocala, Florida, United States
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Ocoee, Florida, United States
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Palmetto Bay, Florida, United States
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Riverview, Florida, United States
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Tampa, Florida, United States
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Atlanta, Georgia, United States
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Columbus, Georgia, United States
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Tucker, Georgia, United States
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Champaign, Illinois, United States
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Chicago, Illinois, United States
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Gurnee, Illinois, United States
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Melrose Park, Illinois, United States
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Moline, Illinois, United States
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Niles, Illinois, United States
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Rockford, Illinois, United States
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Schaumburg, Illinois, United States
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Winfield, Illinois, United States
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Indianapolis, Indiana, United States
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Waterloo, Iowa, United States
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Leavenworth, Kansas, United States
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Wichita, Kansas, United States
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Owensboro, Kentucky, United States
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Bossier City, Louisiana, United States
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Covington, Louisiana, United States
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Lafayette, Louisiana, United States
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New Orleans, Louisiana, United States
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Shreveport, Louisiana, United States
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Zachary, Louisiana, United States
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Annapolis, Maryland, United States
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Baltimore, Maryland, United States
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Lanham, Maryland, United States
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Oxon Hill, Maryland, United States
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Boston, Massachusetts, United States
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Boston, Massachusetts, United States
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New Bedford, Massachusetts, United States
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Worcester, Massachusetts, United States
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Flint, Michigan, United States
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Southfield, Michigan, United States
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Southfield, Michigan, United States
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Troy, Michigan, United States
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Bridgeton, Missouri, United States
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Kansas City, Missouri, United States
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Kansas City, Missouri, United States
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Lincoln, Nebraska, United States
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Bridgewater, New Jersey, United States
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Millville, New Jersey, United States
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Sewell, New Jersey, United States
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Trenton, New Jersey, United States
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Vineland, New Jersey, United States
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Brooklyn, New York, United States
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Buffalo, New York, United States
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New York, New York, United States
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New York, New York, United States
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Rosedale, New York, United States
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The Bronx, New York, United States
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The Bronx, New York, United States
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Chapel Hill, North Carolina, United States
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Durham, North Carolina, United States
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Greensboro, North Carolina, United States
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Statesville, North Carolina, United States
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Wilmington, North Carolina, United States
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Fargo, North Dakota, United States
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Grand Forks, North Dakota, United States
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Columbus, Ohio, United States
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Columbus, Ohio, United States
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Dayton, Ohio, United States
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Maumee, Ohio, United States
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Oklahoma City, Oklahoma, United States
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Bethlehem, Pennsylvania, United States
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Media, Pennsylvania, United States
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Philadelphia, Pennsylvania, United States
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Philadelphia, Pennsylvania, United States
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Smithfield, Pennsylvania, United States
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Yardley, Pennsylvania, United States