Clinical Research Directory

Inclusion Criteria: 1. Age: 18-80 years. 2. Time from onset to enrollment: 8-14 days; if onset time is unknown, time from last known normal to enrollment must be 8-14 days. 3. Meet the following imaging inclusion criteria: 3\. 1 DWI infarct: single (isolated) deep (subcortical) infarct 3.2 The culprit vessel is the lenticulostriate artery, and the DWI lesion meets at least one of the following criteria (A/B): A. comma-shaped infarct expanding fan-wise from bottom to top on coronal view; or B. involvement of ≥3 axial slices (slice thickness 5-7 mm) 3.3 No ≥50% stenosis of the ipsilateral middle cerebral artery (confirmed by MRA, CTA, or DSA) 4. Informed consent form signed by the patient or their legally authorized representative. Exclusion Criteria: 1. Baseline imaging showing intracranial hemorrhagic disease, vascular malformation, space-occupying lesion, or other non-ischemic intracranial pathology. 2. Transient ischemic attack or stroke mimics. 3. Cardioembolic causes: including atrial fibrillation, valvular heart disease, infective endocarditis, etc. 4. Tandem extracranial vascular stenosis ≥50% ipsilateral to the infarct lesion. 5. Prior diagnosis of dementia (Alzheimer's disease, frontotemporal dementia, or Lewy body dementia) or significant cognitive decline (IQCODE \> 3.38). 6. Contraindications to photon-counting CT or 5T-MRI. 7. Pregnancy or lactation. 8. Life expectancy \< 1 year.