Clinical Research Directory

Inclusion Criteria: * Age \> 22 years * Subjects with stable angina pectoris, unstable angina pectoris, or NSTEMI and in whom invasive FFR was performed to assess a non-culprit stenosis in at least one coronary artery * Subject underwent a clinically indicated Invasive Coronary Angiogram (ICA) * Subject underwent invasive FFR with intravenous (IV) or intracoronary adenosine, or adenosine triphosphate (ATP), as hyperemic stimulus Exclusion Criteria: * Angiogram not obtained on a United States Food and Drug Administration (FDA)-cleared C-arm angiography system * Invasive FFR not obtained on an FDA-cleared FFR catheter tip pressure transducer (also known as a pressure wire) * Vessel size less than 2 mm * Subject presents with an ST-elevation myocardial infarction (STEMI) * Chronic total occlusion (CTO) in target vessel * Prior coronary artery bypass graft (CABG) surgery, heart transplant or valve surgery, prior transcatheter aortic valve implantation/replacement (TAVI/TAVR), or severe left-sided valvular disease * Known left ventricular ejection fraction (LVEF) ≤ 30% * Arteries supplying akinetic or severe hypokinetic territories on target lesion, if already known based on prior imaging * Thrombolysis in Myocardial Infarction (TIMI) flow grade equal to or lower than 2 at baseline * Target lesion involves Left Main (stenosis \>50%) * Percutaneous coronary intervention (PCI) with stent in target vessel in past 12 months, or target vessel involves in-stent restenosis * Target coronary vessel provides collaterals to a chronically occluded vessel * Coronary angiography was not performed per standard of care at a cine frame rate of at least 7 frames per second * Presence of aortic damping * Distortion of the waveform * Less than two different angiographic views for each lesion of interest in the Left Circumflex Artery (LCX), Left Anterior Descending Artery (LAD), or Right Coronary Artery (RCA) * Lesion is not clearly visible