Clinical Research Directory
Browse clinical research sites, groups, and studies.
Platelet-Rich Fibrin as an Antibiotic Delivery Vehicle in Mandibular Third Molar Surgery
Sponsor: Amerigo Giudice
Summary
The present study aims to evaluate the effect of platelet-rich fibrin (PRF) used as a local antibiotic delivery vehicle on postoperative outcomes, including facial swelling, trismus, and pain, following mandibular third molar surgery in a randomized split-mouth clinical trial.
Official title: Effects of Antibiotic-Prepared Platelet-Rich Fibrin on Postoperative Recovery After Mandibular Third Molar Surgery: A Randomized Split-Mouth Clinical Trial
Key Details
Gender
All
Age Range
18 Years - 32 Years
Study Type
INTERVENTIONAL
Enrollment
31
Start Date
2025-11-01
Completion Date
2026-11-20
Last Updated
2026-08-20
Healthy Volunteers
Yes
Conditions
Interventions
Antibiotic-enriched Platelet-Rich Fibrin (PRF)
Platelet-rich fibrin prepared with the addition of antibiotic prior to centrifugation and applied into the mandibular third molar extraction socket to provide local antibiotic delivery.
Platelet-Rich Fibrin (PRF)
Standard platelet-rich fibrin prepared without antibiotic addition and applied into the mandibular third molar extraction socket.
Locations (1)
Magna Graecia University of Catanzaro
Catanzaro, cz, Italy