Clinical Research Directory

Inclusion Criteria: 1. Enrollment in the Rugao Longevity and Ageing Study or the Shanghai Older-Adult Cohort. 2. Age 60 years or older, of either sex, with a baseline estimated glomerular filtration rate greater than 60 mL/min/1.73 m². 3. Availability of the baseline data required for the study, including blood pressure, body weight, body mass index, smoking and alcohol use, surgical history, family history, complete blood count, liver function, electrolytes, kidney function, serum cystatin C, blood glucose, urinalysis, and urinary albumin-to-creatinine ratio. 4. Availability of follow-up information sufficient to ascertain the prespecified clinical outcomes. 5. Clinically stable condition and adequate ability to understand and communicate at enrollment in the parent cohort. 6. Written informed consent for participation and the permitted research use of clinical data and stored biospecimens. Exclusion Criteria: 1. Missing essential baseline or follow-up data required for the relevant analysis. 2. Unavailability of stored blood or urine specimens required for the planned biomarker analysis. 3. Missing information on lifestyle, health-related behaviors, or social support required for the relevant analysis.