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Subclinical Myocardial Dysfunction in Children With Wilson's Disease
Sponsor: Hebatullah Fawzy
Summary
Wilson's disease (WD) is one of the most common metabolic liver diseases in older children. The most frequent clinical presentation is liver disease. However, Wilson's disease (WD) is a multisystem disorder. It is concluded that four modes of cardiac manifestations in Wilson's disease (WD) include arrhythmias, cardiomyopathy, cardiac death, and autonomic dysfunction. Such possible cardiac involvement should be added to the clinical picture of Wilson's disease (WD) involving the hepatic and central nervous system(CNS). The data on cardiac manifestations in children is very limited and only few adult studies are available. In this study, the investigators aim to unveil subclinical cardiac dysfunction in children with Wilson's disease with apparently normal cardiac functions by conventional assessment.
Official title: Assessment of Subtle Myocardial Dysfunction in Children With Wilson's Disease: A Case-Control Study
Key Details
Gender
All
Age Range
4 Years - 18 Years
Study Type
OBSERVATIONAL
Enrollment
72
Start Date
2025-10-01
Completion Date
2026-11-30
Last Updated
2026-08-14
Healthy Volunteers
Yes
Conditions
Interventions
Echocardiography
a safe, painless test that uses sound waves to create moving pictures of your heart's structure and pumping function.
Electrocardiography
a quick, painless test that records the electrical signals in the heart.
N-terminal pro b- type natriuretic peptide
a protein made by our heart, examined by peripheral blood sample.
Locations (2)
Faculty of medicine AinShams U
Cairo, Egypt
National Hepatology and Tropical Research Institute (NHTMRI)
Giza, Egypt