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A Study of SPY072 in Adults With Moderate to Severe Hidradenitis Suppurativa (The SKYLIGHT Trial)
Sponsor: Spyre Therapeutics, Inc.
Summary
This Phase 2 study will test whether the investigational medicine, SPY072, improves hidradenitis suppurativa (HS) in adults with moderate to severe disease receiving advanced standard of care treatment. About 150 participants will be assigned by chance to receive either SPY072 or placebo for 16 weeks. Participants will be followed after the treatment period to evaluate safety and how long treatment effects may last.
Official title: A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled, Proof-of-concept Trial to Assess the Efficacy and Safety of SPY072 in Adults With Moderate to Severe Hidradenitis Suppurativa Receiving Standard of Care Treatment
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
150
Start Date
2026-09
Completion Date
2028-06
Last Updated
2026-10-19
Healthy Volunteers
No
Conditions
Interventions
SPY072
Solution for SC injection
Placebo
Matching placebo for SC injection
bimekizumab
Advanced standard of care
Locations (34)
Site 117
Birmingham, Alabama, United States
Site 119
Rogers, Arkansas, United States
Site 111
Irvine, California, United States
Site 113
Coral Gables, Florida, United States
Site 115
Atlanta, Georgia, United States
Site 101
Indianapolis, Indiana, United States
Site 100
Bowling Green, Kentucky, United States
Site 116
Owensboro, Kentucky, United States
Site 108
Baton Rouge, Louisiana, United States
Site 103
Boston, Massachusetts, United States
Site 112
Boston, Massachusetts, United States
Site 127
Detroit, Michigan, United States
Site 120
Las Vegas, Nevada, United States
Site 126
Las Vegas, Nevada, United States
Site 102
New York, New York, United States
Site 104
The Bronx, New York, United States
Site 124
Durham, North Carolina, United States
Site 122
Oklahoma City, Oklahoma, United States
Site 109
Mt. Pleasant, South Carolina, United States
Site 125
Nashville, Tennessee, United States
Site 118
Smyrna, Tennessee, United States
Site 114
Prosper, Texas, United States
Site 107
Tyler, Texas, United States
Site 121
Tyler, Texas, United States
Site 123
Murray, Utah, United States
Site 106
Mill Creek, Washington, United States
Site 163
Edmonton, Alberta, Canada
Site 165
Surrey, British Columbia, Canada
Site 164
Winnipeg, Manitoba, Canada
Site 160
Barrie, Ontario, Canada
Site 167
Markham, Ontario, Canada
Site 162
Richmond Hill, Ontario, Canada
Site 166
Québec, Quebec, Canada
Site 161
Saskatoon, Saskatchewan, Canada