Clinical Research Directory

Inclusion Criteria: * female, age ≥18 and ≤89 years old * any race/ethnicity * English and/or Spanish fluency * undergoing apical suspension: * sacrocolpopexy (laparoscopic or robotic) * uterosacral ligament suspension (vaginal, laparoscopic, or robotic) * sacrospinous ligament fixation * iliococcygeus suspension * surgery being performed at Hartford Hospital Exclusion Criteria: * male * age \<18 or ≥90 years old * pregnant * breastfeeding * documented diagnosis of hypotension in EMR problem list, BP in office or at pre-op PAC (confirmed on repeat) to be systolic \<100 mm Hg and/or diastolic \<70 mm Hg * known intolerance or sensitivity to tizanidine * current use of: * CYP1A2 inhibitor: * clonidine (alpha-2 agonist) antihypertensive * opioid * muscle relaxant * pre-existing * hepatic impairment as defined as transaminitis with ALT or AST \>2x upper limit of normal * diagnoses of cirrhosis, alcoholic liver disease, non-alcoholic fatty liver disease (NAFLD) * renal impairment as defined by creatinine clearance \<25 mL/min * obstructive sleep apnea * non-English or non-Spanish speaking * past opioid dependence * concurrent diagnosis of malignancy * concurrent surgery apart from pelvic reconstructive surgery with another specialty * unable/unwilling to consent to participate